Frontiers in Microbiology (Nov 2023)
Comparison of Lactiplantibacillus plantarum isolates from the gut of mice supplemented with different types of nutrients: a genomic and metabolomic study
- Ziyan Wang,
- Ziyan Wang,
- Ziyan Wang,
- Zhixuan Zhang,
- Zhixuan Zhang,
- Zhixuan Zhang,
- Qiuyue Shi,
- Qiuyue Shi,
- Qiuyue Shi,
- Songyi Liu,
- Songyi Liu,
- Songyi Liu,
- Qiaoli Wu,
- Qiaoli Wu,
- Qiaoli Wu,
- Ze Wang,
- Ze Wang,
- Ze Wang,
- Emilaguli Saiding,
- Emilaguli Saiding,
- Emilaguli Saiding,
- Jiaojiao Han,
- Jiaojiao Han,
- Jiaojiao Han,
- Jun Zhou,
- Jun Zhou,
- Jun Zhou,
- Rixin Wang,
- Rixin Wang,
- Xiurong Su,
- Xiurong Su,
- Xiurong Su
Affiliations
- Ziyan Wang
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Ziyan Wang
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Ziyan Wang
- School of Marine Sciences, Ningbo University, Ningbo, China
- Zhixuan Zhang
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Zhixuan Zhang
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Zhixuan Zhang
- School of Marine Sciences, Ningbo University, Ningbo, China
- Qiuyue Shi
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Qiuyue Shi
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Qiuyue Shi
- School of Marine Sciences, Ningbo University, Ningbo, China
- Songyi Liu
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Songyi Liu
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Songyi Liu
- School of Marine Sciences, Ningbo University, Ningbo, China
- Qiaoli Wu
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Qiaoli Wu
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Qiaoli Wu
- School of Marine Sciences, Ningbo University, Ningbo, China
- Ze Wang
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Ze Wang
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Ze Wang
- School of Marine Sciences, Ningbo University, Ningbo, China
- Emilaguli Saiding
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Emilaguli Saiding
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Emilaguli Saiding
- School of Marine Sciences, Ningbo University, Ningbo, China
- Jiaojiao Han
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Jiaojiao Han
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Jiaojiao Han
- School of Marine Sciences, Ningbo University, Ningbo, China
- Jun Zhou
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Jun Zhou
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Jun Zhou
- School of Marine Sciences, Ningbo University, Ningbo, China
- Rixin Wang
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Rixin Wang
- School of Marine Sciences, Ningbo University, Ningbo, China
- Xiurong Su
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Ningbo, China
- Xiurong Su
- Key Laboratory of Aquacultural Biotechnology Ministry of Education, Ningbo University, Ningbo, China
- Xiurong Su
- School of Marine Sciences, Ningbo University, Ningbo, China
- DOI
- https://doi.org/10.3389/fmicb.2023.1295058
- Journal volume & issue
-
Vol. 14
Abstract
Many studies have focused on the influence of dietary supplements on gut microbiota composition, but limited research have reported their effects on specific bacterial species in the gut. Lactiplantibacillus plantarum is one of the most widely studied probiotics, with a wide range of sources and good environmental adaptability. In this study, in order to elucidate the adaptation strategies of L. plantarum to the gut of mice supplemented with carbohydrates, peptides and minerals, whole genome resequencing and intracellular metabolites detection were performed, and high-frequency mutant genes and differential metabolites were screened. The results suggested different types of dietary supplements do have different effects on L. plantarum from the gut of mice. Additionally, KEGG annotation unveiled that the effects of these dietary supplements on the gene level of L. plantarum primarily pertained to environmental information processing, while the differential metabolites were predominantly associated with metabolism. This study provided new perspectives on the adaptive mechanism of L. plantarum in response to the host’s gut environment, suggesting that the diversity of the genome and metabolome of L. plantarum was correlated with dietary supplements. Furthermore, this study offered useful guidance in the effective utilization of dietary supplements.
Keywords
- Lactiplantibacillus plantarum
- dietary supplements
- whole-genome resequencing
- intracellular metabolites
- environmental adaptability
