Nature Communications (Feb 2018)

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

  • Ladan Khodaparast,
  • Laleh Khodaparast,
  • Rodrigo Gallardo,
  • Nikolaos N. Louros,
  • Emiel Michiels,
  • Reshmi Ramakrishnan,
  • Meine Ramakers,
  • Filip Claes,
  • Lydia Young,
  • Mohammad Shahrooei,
  • Hannah Wilkinson,
  • Matyas Desager,
  • Wubishet Mengistu Tadesse,
  • K. Peter R. Nilsson,
  • Per Hammarström,
  • Abram Aertsen,
  • Sebastien Carpentier,
  • Johan Van Eldere,
  • Frederic Rousseau,
  • Joost Schymkowitz

DOI
https://doi.org/10.1038/s41467-018-03131-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell death, which could serve as antibacterial strategy.