Association Between InDel and CNV Variation in the <i>FBLN1</i> Gene and Slaughter Traits in Cattle
Hongye Gu,
Qihui Zhu,
Yafang Li,
Yuli Zhang,
Chiyuan Zhang,
Cui Mao,
Fugui Jiang,
Chuanying Pan,
Xianyong Lan,
Tianyu Deng
Affiliations
Hongye Gu
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Qihui Zhu
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Yafang Li
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Yuli Zhang
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Chiyuan Zhang
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Cui Mao
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Fugui Jiang
Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China
Chuanying Pan
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Xianyong Lan
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Tianyu Deng
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
The FBLN1 gene encodes the fibulin-1 protein, the first member of the ECM glycoprotein family, and is crucial for embryonic development and organ tissue formation in mammals. Our previous transcriptome analysis identified the FBLN1 gene and suggested its potential role in influencing slaughter traits by regulating ECM function. This study aims to uncover key genetic variants (InDel and CNV) within the FBLN1 gene and examine its relationship with slaughter traits in beef cattle. In this study, the beef cattle genetic resources population Gaoqing black cattle were selected (n = 641), leading to the identification of three polymorphic InDel loci (13 bp insertion, 28 bp insertion, and 24 bp insertion) and two CNVs. Association analysis revealed that InDel polymorphisms in Gaoqing black cattle were significantly correlated with certain slaughter traits (p p p FBLN1 gene represent potential molecular markers associated with slaughter traits in Gaoqing black cattle. These findings provide valuable insights for marker-assisted selection to enhance genetic improvement in beef cattle breeding.
