Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

Sara Badodi; Nicola Pomella; Xinyu Zhang; Gabriel Rosser; John Whittingham; Maria Victoria Niklison-Chirou; Yau Mun Lim; Sebastian Brandner; Gillian Morrison; Steven M. Pollard; Christopher D. Bennett; Steven C. Clifford; Andrew Peet; M. Albert Basson; Silvia Marino

doi:10.1038/s41467-021-22379-7

Nature Communications (Apr 2021)

Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

Sara Badodi,
Nicola Pomella,
Xinyu Zhang,
Gabriel Rosser,
John Whittingham,
Maria Victoria Niklison-Chirou,
Yau Mun Lim,
Sebastian Brandner,
Gillian Morrison,
Steven M. Pollard,
Christopher D. Bennett,
Steven C. Clifford,
Andrew Peet,
M. Albert Basson,
Silvia Marino

Affiliations

Sara Badodi: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Nicola Pomella: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Xinyu Zhang: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Gabriel Rosser: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
John Whittingham: Centre for Craniofacial and Regenerative Biology, King’s College London
Maria Victoria Niklison-Chirou: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Yau Mun Lim: UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust
Sebastian Brandner: UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust
Gillian Morrison: Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, The University of Edinburgh
Steven M. Pollard: Centre for Regenerative Medicine & Cancer Research UK Edinburgh Centre, The University of Edinburgh
Christopher D. Bennett: Institute of Cancer and Genomic Sciences, University of Birmingham
Steven C. Clifford: Newcastle University Centre for Cancer, Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute
Andrew Peet: Institute of Cancer and Genomic Sciences, University of Birmingham
M. Albert Basson: Centre for Craniofacial and Regenerative Biology, King’s College London
Silvia Marino: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London

DOI: https://doi.org/10.1038/s41467-021-22379-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alone or in combination with chemotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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