HemaSphere (Aug 2022)

2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia

  • Dimitrios Farmakis,
  • John Porter,
  • Ali Taher,
  • Maria Domenica Cappellini,
  • Michael Angastiniotis,
  • Androulla Eleftheriou,
  • for the 2021 TIF Guidelines Taskforce*,
  • John Porter,
  • Ali Taher,
  • Maria Domenica Cappellini,
  • Dimitrios Farmakis,
  • Ali Alassaf,
  • Michael Angastiniotis,
  • Emanuele Angelucci,
  • Yesim Aydinok,
  • Rayan Bou-Fakhredin Rayan,
  • Loris Brunetta,
  • Maria Domenica Cappellini,
  • George Constantinou,
  • Shahina Daar,
  • Vincenzo De Sanctis,
  • Geoffrey Dusheiko,
  • Riyad Elbard,
  • Androulla Eleftheriou,
  • Perla Eleftheriou,
  • Panos Englezos,
  • Dimitrios Farmakis,
  • Dru Haines,
  • Faiez N Hattab,
  • George Kaltsounis,
  • Antonios Kattamis,
  • John Koskinas,
  • Navdeep Kumar,
  • Andreas Kulozik,
  • Andreas Kyriakou,
  • Aurelio Maggio,
  • Roanna Maharai,
  • Lauren Mednick,
  • Eleni Michalaki,
  • Wendy Murphy,
  • Lena Oevermann,
  • Raffaella Origa,
  • Penelope-Georgia Papayanni,
  • Constantina Politis,
  • John Porter,
  • Farukh Shah,
  • Anton Skafi,
  • Nikos Skordis,
  • Pietro Sodani,
  • Ashraf Soliman,
  • Seni Subair,
  • Ali Taher,
  • Maria Tampaki,
  • Sara Trompeter,
  • Shobha Tuli,
  • Malcolm Walker,
  • Robert Yamashita,
  • Evangelia Yannaki,
  • Anne Yardumian

DOI
https://doi.org/10.1097/HS9.0000000000000732
Journal volume & issue
Vol. 6, no. 8
p. e732

Abstract

Read online

Beta-thalassemia and particularly its transfusion-dependent form (TDT) is a demanding clinical condition, requiring life-long care and follow-up, ideally in specialized centers and by multidisciplinary teams of experts. Despite the significant progress in TDT diagnosis and treatment over the past decades that has dramatically improved patients’ prognosis, its management remains challenging. On one hand, diagnostic and therapeutic advances are not equally applied to all patients across the world, particularly in several high-prevalence eastern regions. On the other, healthcare systems in low-prevalence western countries that have recently received large numbers of migrant thalassemia patients, were not ready to address patients’ special needs. Thalassaemia International Federation (TIF), a global patient-driven umbrella federation with 232 member-associations in 62 countries, strives for equal access to quality care for all patients suffering from thalassemia or other hemoglobinopathies in every part of the world by promoting education, research, awareness, and advocacy. One of TIF’s main actions is the development and dissemination of clinical practice guidelines for the management of these patients. In 2021, the fourth edition of TIF’s guidelines for the management of TDT was published. The full text provides detailed information on the management of TDT patients and the clinical presentation, pathophysiology, diagnostic approach, and treatment of disease complications or other clinical entities that may occur in these patients, while also covering relevant psychosocial and organizational issues. The present document is a summary of the 2021 TIF guidelines for TDT that focuses mainly on clinical practice issues and recommendations.