eLife (Aug 2020)
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study
- David W Eyre,
- Sheila F Lumley,
- Denise O'Donnell,
- Mark Campbell,
- Elizabeth Sims,
- Elaine Lawson,
- Fiona Warren,
- Tim James,
- Stuart Cox,
- Alison Howarth,
- George Doherty,
- Stephanie B Hatch,
- James Kavanagh,
- Kevin K Chau,
- Philip W Fowler,
- Jeremy Swann,
- Denis Volk,
- Fan Yang-Turner,
- Nicole Stoesser,
- Philippa C Matthews,
- Maria Dudareva,
- Timothy Davies,
- Robert H Shaw,
- Leon Peto,
- Louise O Downs,
- Alexander Vogt,
- Ali Amini,
- Bernadette C Young,
- Philip George Drennan,
- Alexander J Mentzer,
- Donal T Skelly,
- Fredrik Karpe,
- Matt J Neville,
- Monique Andersson,
- Andrew J Brent,
- Nicola Jones,
- Lucas Martins Ferreira,
- Thomas Christott,
- Brian D Marsden,
- Sarah Hoosdally,
- Richard Cornall,
- Derrick W Crook,
- David I Stuart,
- Gavin Screaton,
- Oxford University Hospitals Staff Testing Group,
- Timothy EA Peto,
- Bruno Holthof,
- Anne-Marie O'Donnell,
- Daniel Ebner,
- Christopher P Conlon,
- Katie Jeffery,
- Timothy M Walker
Affiliations
- David W Eyre
- ORCiD
- Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at University of Oxford in partnership with Public Health England, Oxford, United Kingdom
- Sheila F Lumley
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Denise O'Donnell
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Mark Campbell
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Elizabeth Sims
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Elaine Lawson
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Fiona Warren
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Tim James
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Stuart Cox
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Alison Howarth
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- George Doherty
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Stephanie B Hatch
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Target Discovery Institute, University of Oxford, Oxford, United Kingdom
- James Kavanagh
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Kevin K Chau
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Philip W Fowler
- ORCiD
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Jeremy Swann
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Denis Volk
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Fan Yang-Turner
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Nicole Stoesser
- ORCiD
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at University of Oxford in partnership with Public Health England, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Philippa C Matthews
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Maria Dudareva
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Timothy Davies
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Robert H Shaw
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Leon Peto
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Louise O Downs
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Alexander Vogt
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Ali Amini
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Bernadette C Young
- ORCiD
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Philip George Drennan
- ORCiD
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Alexander J Mentzer
- ORCiD
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Donal T Skelly
- ORCiD
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
- Fredrik Karpe
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
- Matt J Neville
- ORCiD
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
- Monique Andersson
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Andrew J Brent
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Nicola Jones
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Lucas Martins Ferreira
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Thomas Christott
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Brian D Marsden
- ORCiD
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Kennedy Institute of Rheumatology Research, University of Oxford, Oxford, United Kingdom
- Sarah Hoosdally
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Richard Cornall
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Derrick W Crook
- ORCiD
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- David I Stuart
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Gavin Screaton
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Oxford University Hospitals Staff Testing Group
- Timothy EA Peto
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Bruno Holthof
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Anne-Marie O'Donnell
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Daniel Ebner
- ORCiD
- Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Target Discovery Institute, University of Oxford, Oxford, United Kingdom
- Christopher P Conlon
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
- Katie Jeffery
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
- Timothy M Walker
- Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam
- DOI
- https://doi.org/10.7554/eLife.60675
- Journal volume & issue
-
Vol. 9
Abstract
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]).
Keywords
