Nature Communications (Jan 2022)

Functional dissection of inherited non-coding variation influencing multiple myeloma risk

  • Ram Ajore,
  • Abhishek Niroula,
  • Maroulio Pertesi,
  • Caterina Cafaro,
  • Malte Thodberg,
  • Molly Went,
  • Erik L. Bao,
  • Laura Duran-Lozano,
  • Aitzkoa Lopez de Lapuente Portilla,
  • Thorunn Olafsdottir,
  • Nerea Ugidos-Damboriena,
  • Olafur Magnusson,
  • Mehmet Samur,
  • Caleb A. Lareau,
  • Gisli H. Halldorsson,
  • Gudmar Thorleifsson,
  • Gudmundur L. Norddahl,
  • Kristbjorg Gunnarsdottir,
  • Asta Försti,
  • Hartmut Goldschmidt,
  • Kari Hemminki,
  • Frits van Rhee,
  • Scott Kimber,
  • Adam S. Sperling,
  • Martin Kaiser,
  • Kenneth Anderson,
  • Ingileif Jonsdottir,
  • Nikhil Munshi,
  • Thorunn Rafnar,
  • Anders Waage,
  • Niels Weinhold,
  • Unnur Thorsteinsdottir,
  • Vijay G. Sankaran,
  • Kari Stefansson,
  • Richard Houlston,
  • Björn Nilsson

DOI
https://doi.org/10.1038/s41467-021-27666-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

The causality and functional roles of disease-associated variants revealed by genome-wide association studies (GWAS) are mostly unexplored. Here the authors identify putative causal variants in multiple myeloma and find their association with gene expression and chromatin accessibility.