Nature Communications (Jan 2022)
Functional dissection of inherited non-coding variation influencing multiple myeloma risk
- Ram Ajore,
- Abhishek Niroula,
- Maroulio Pertesi,
- Caterina Cafaro,
- Malte Thodberg,
- Molly Went,
- Erik L. Bao,
- Laura Duran-Lozano,
- Aitzkoa Lopez de Lapuente Portilla,
- Thorunn Olafsdottir,
- Nerea Ugidos-Damboriena,
- Olafur Magnusson,
- Mehmet Samur,
- Caleb A. Lareau,
- Gisli H. Halldorsson,
- Gudmar Thorleifsson,
- Gudmundur L. Norddahl,
- Kristbjorg Gunnarsdottir,
- Asta Försti,
- Hartmut Goldschmidt,
- Kari Hemminki,
- Frits van Rhee,
- Scott Kimber,
- Adam S. Sperling,
- Martin Kaiser,
- Kenneth Anderson,
- Ingileif Jonsdottir,
- Nikhil Munshi,
- Thorunn Rafnar,
- Anders Waage,
- Niels Weinhold,
- Unnur Thorsteinsdottir,
- Vijay G. Sankaran,
- Kari Stefansson,
- Richard Houlston,
- Björn Nilsson
Affiliations
- Ram Ajore
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Abhishek Niroula
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Maroulio Pertesi
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Caterina Cafaro
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Malte Thodberg
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Molly Went
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Erik L. Bao
- Broad Institute of Massachusetts Institute of Technology and Harvard University
- Laura Duran-Lozano
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Aitzkoa Lopez de Lapuente Portilla
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Thorunn Olafsdottir
- deCODE Genetics/Amgen Inc.
- Nerea Ugidos-Damboriena
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- Olafur Magnusson
- deCODE Genetics/Amgen Inc.
- Mehmet Samur
- Dana-Farber Cancer Institute, Harvard Medical School
- Caleb A. Lareau
- Broad Institute of Massachusetts Institute of Technology and Harvard University
- Gisli H. Halldorsson
- deCODE Genetics/Amgen Inc.
- Gudmar Thorleifsson
- deCODE Genetics/Amgen Inc.
- Gudmundur L. Norddahl
- deCODE Genetics/Amgen Inc.
- Kristbjorg Gunnarsdottir
- deCODE Genetics/Amgen Inc.
- Asta Försti
- German Cancer Research Center (DKFZ)
- Hartmut Goldschmidt
- Department of Internal Medicine V, University Hospital of Heidelberg
- Kari Hemminki
- German Cancer Research Center (DKFZ)
- Frits van Rhee
- Hopp Children’s Cancer Center
- Scott Kimber
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Adam S. Sperling
- Dana-Farber Cancer Institute, Harvard Medical School
- Martin Kaiser
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Kenneth Anderson
- Dana-Farber Cancer Institute, Harvard Medical School
- Ingileif Jonsdottir
- deCODE Genetics/Amgen Inc.
- Nikhil Munshi
- Dana-Farber Cancer Institute, Harvard Medical School
- Thorunn Rafnar
- deCODE Genetics/Amgen Inc.
- Anders Waage
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology
- Niels Weinhold
- German Cancer Research Center (DKFZ)
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen Inc.
- Vijay G. Sankaran
- Broad Institute of Massachusetts Institute of Technology and Harvard University
- Kari Stefansson
- deCODE Genetics/Amgen Inc.
- Richard Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Björn Nilsson
- Hematology and Transfusion Medicine, Department of Laboratory Medicine
- DOI
- https://doi.org/10.1038/s41467-021-27666-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The causality and functional roles of disease-associated variants revealed by genome-wide association studies (GWAS) are mostly unexplored. Here the authors identify putative causal variants in multiple myeloma and find their association with gene expression and chromatin accessibility.
