A multidisciplinary study of chemico-physical properties of different classes of 2-aryl-5(or 6)-nitrobenzimidazoles: NMR, electrochemical behavior, ESR, and DFT calculations

Abstract

Continuing in our researches on the syntheses, reactivity, pharmacological/biological activities of heterocyclic compounds containing one or more nitrogen atoms we have examined some chemico-physical properties (1H and 13C NMR, electrochemical behavior, and ESR) of three series of 2-aryl-5(or 6)-nitrobenzimidazoles (1–3) variously substituted in the 2-aryl ring. The electrochemical behavior of the nitro group on the benzimidazole ring has been studied by cyclic voltammetry. This has allowed to point out both the reversibility, the formal potential, and the number of electrons involved in the electrochemical processes, and to evaluate the effect of the substituents present on the aryl ring. The data collected have been able to furnish a complete picture of electronic distribution and have been supported by DFT calculations.

Keywords

• 2-Aryl-nitrobenzimidazoles
• 1H and 13C NMR
• Cyclic voltammetry
• Electron spin resonance
• DFT calculations