Hierarchical overlapping modular structure in the human cerebral cortex improves individual identification

Abstract

Summary: The idea that brain networks have a hierarchical modular organization is pervasive. Increasing evidence suggests that brain modules overlap. However, little is known about the hierarchical overlapping modular structure in the brain. In this study, we developed a framework to uncover brain hierarchical overlapping modular structures based on a nested-spectral partition algorithm and an edge-centric network model. Overlap degree between brain modules is symmetrical across hemispheres, with highest overlap observed in the control and salience/ventral attention networks. Furthermore, brain edges are clustered into two groups: intrasystem and intersystem edges, to form hierarchical overlapping modules. At different levels, modules are self-similar in the degree of overlap. Additionally, the brain’s hierarchical structure contains more individual identifiable information than a single-level structure, particularly in the control and salience/ventral attention networks. Our results offer pathways for future studies aimed at relating the organization of hierarchical overlapping modules to brain cognitive behavior and disorders.

Keywords

• Systems neuroscience
• Cognitive neuroscience