Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats

Kuan Zeng; Kuan Zeng; Aimin Xie; Aimin Xie; Xiaojie Zhang; Baoliang Zhong; Baoliang Zhong; Xuebing Liu; Xuebing Liu; Wei Hao

doi:10.3389/fpsyt.2018.00468

Frontiers in Psychiatry (Oct 2018)

Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats

Kuan Zeng,
Kuan Zeng,
Aimin Xie,
Aimin Xie,
Xiaojie Zhang,
Baoliang Zhong,
Baoliang Zhong,
Xuebing Liu,
Xuebing Liu,
Wei Hao

Affiliations

Kuan Zeng: Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan, China
Kuan Zeng: Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China
Aimin Xie: Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan, China
Aimin Xie: Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China
Xiaojie Zhang: Key Laboratory of Psychiatry and Mental Health of Hunan Province, China National Clinical Research Center for Mental Health Disorders, Mental Health Institute of the Second Xiangya Hospital, National Technology Institute of Psychiatry, Central South University, Changsha, China
Baoliang Zhong: Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan, China
Baoliang Zhong: Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China
Xuebing Liu: Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan, China
Xuebing Liu: Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China
Wei Hao: Key Laboratory of Psychiatry and Mental Health of Hunan Province, China National Clinical Research Center for Mental Health Disorders, Mental Health Institute of the Second Xiangya Hospital, National Technology Institute of Psychiatry, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fpsyt.2018.00468
Journal volume & issue: Vol. 9

Abstract

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Gamma-aminobutyric acid (GABA)-Aα5 is considered to be associated with alcohol-induced memory deficits. However, whether it participates in the formation of alcohol addiction or in the regulation of its susceptibility is unknown. Here, we used a chronic alcohol treatment model to obtain alcohol-addicted Wistar rats. Long-term alcoholism increased the expression of prefrontal cortex GABA-Aα5 by inducing its histone H3K4 trimethylation, and these changes could be hereditary and lead to increased vulnerability to alcohol addiction in offspring. This study indicates the risk of long-term alcoholism in future generations, emphasizes the importance of GABA-Aα5 in the formation of alcohol addiction and the regulation of its susceptibility, and provides new evidence regarding the mechanisms underlying alcohol addiction.

Published in Frontiers in Psychiatry

ISSN: 1664-0640 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.frontiersin.org/journals/psychiatry

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