Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Elham Assadpour; Atefe Rezaei; Sabya Sachi Das; Balaga Venkata Krishna Rao; Sandeep Kumar Singh; Mohammad Saeed Kharazmi; Niraj Kumar Jha; Saurabh Kumar Jha; Miguel A. Prieto; Seid Mahdi Jafari

doi:10.3390/ph16040487

Pharmaceuticals (Mar 2023)

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Elham Assadpour,
Atefe Rezaei,
Sabya Sachi Das,
Balaga Venkata Krishna Rao,
Sandeep Kumar Singh,
Mohammad Saeed Kharazmi,
Niraj Kumar Jha,
Saurabh Kumar Jha,
Miguel A. Prieto,
Seid Mahdi Jafari

Affiliations

Elham Assadpour: Food Industry Research Co., Gorgan 49138-15739, Iran
Atefe Rezaei: Department of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Sabya Sachi Das: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India
Balaga Venkata Krishna Rao: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India
Sandeep Kumar Singh: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India
Mohammad Saeed Kharazmi: Faculty of Medicine, University of California, Riverside, CA 92679, USA
Niraj Kumar Jha: Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida 201310, India
Saurabh Kumar Jha: Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida 201310, India
Miguel A. Prieto: Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, E-32004 Ourense, Spain
Seid Mahdi Jafari: Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, E-32004 Ourense, Spain

DOI: https://doi.org/10.3390/ph16040487
Journal volume & issue: Vol. 16, no. 4
p. 487

Abstract

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Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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