Biomedicines (Jan 2023)

New Nitric Oxide-Releasing Compounds as Promising Anti-Bladder Cancer Drugs

  • María Varela,
  • Miriam López,
  • Mariana Ingold,
  • Diego Alem,
  • Valentina Perini,
  • Karen Perelmuter,
  • Mariela Bollati-Fogolín,
  • Gloria V. López,
  • Paola Hernández

DOI
https://doi.org/10.3390/biomedicines11010199
Journal volume & issue
Vol. 11, no. 1
p. 199

Abstract

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Bladder cancer is a worldwide problem and improved therapies are urgently needed. In the search for newer strong antitumor compounds, herein, we present the study of three nitric oxide-releasing compounds and evaluate them as possible therapies for this malignancy. Bladder cancer cell lines T24 and 253J were used to evaluate the antiproliferative, antimigratory, and genotoxic effects of compounds. Moreover, we determined the NF-κB pathway inhibition, and finally, the survivin downregulation exerted by our molecules. The results revealed that compounds 1 and 3 exerted a high antiproliferative activity against bladder cancer cells through DNA damage and survivin downregulation. In addition, compound 3 reduced bladder cancer cell migration. We found that nitric oxide donors are promising molecules for the development of a new therapeutic targeting the underlying mechanisms of tumorigenesis and progression of bladder cancer.

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