Nature Communications (Aug 2022)
Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression
- Moh’d Mohanad Al-Dabet,
- Khurrum Shahzad,
- Ahmed Elwakiel,
- Alba Sulaj,
- Stefan Kopf,
- Fabian Bock,
- Ihsan Gadi,
- Silke Zimmermann,
- Rajiv Rana,
- Shruthi Krishnan,
- Dheerendra Gupta,
- Jayakumar Manoharan,
- Sameen Fatima,
- Sumra Nazir,
- Constantin Schwab,
- Ronny Baber,
- Markus Scholz,
- Robert Geffers,
- Peter Rene Mertens,
- Peter P. Nawroth,
- John H. Griffin,
- Maria Keller,
- Chris Dockendorff,
- Shrey Kohli,
- Berend Isermann
Affiliations
- Moh’d Mohanad Al-Dabet
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Khurrum Shahzad
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Ahmed Elwakiel
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Alba Sulaj
- Internal Medicine I and Clinical Chemistry, German Diabetes Center (DZD), University of Heidelberg
- Stefan Kopf
- Internal Medicine I and Clinical Chemistry, German Diabetes Center (DZD), University of Heidelberg
- Fabian Bock
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Ihsan Gadi
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Silke Zimmermann
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Rajiv Rana
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Shruthi Krishnan
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Dheerendra Gupta
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Jayakumar Manoharan
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Sameen Fatima
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Sumra Nazir
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Constantin Schwab
- Institute of Pathology, University of Heidelberg
- Ronny Baber
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University
- Robert Geffers
- Genome Analytics, Helmholtz Centre for Infection Research
- Peter Rene Mertens
- Clinic of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University
- Peter P. Nawroth
- Internal Medicine I and Clinical Chemistry, German Diabetes Center (DZD), University of Heidelberg
- John H. Griffin
- Department of Molecular Medicine, The Scripps Research Institute
- Maria Keller
- Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich at the University of Leipzig and University Hospital Leipzig
- Chris Dockendorff
- Department of Chemistry, Marquette University
- Shrey Kohli
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- Berend Isermann
- Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig University
- DOI
- https://doi.org/10.1038/s41467-022-32477-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyperglycemic memory, the suppression of which improves hyperglycemic memory and renal function.
