Nature Communications (May 2021)
Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
- Nicholas D. Walter,
- Sarah E. M. Born,
- Gregory T. Robertson,
- Matthew Reichlen,
- Christian Dide-Agossou,
- Victoria A. Ektnitphong,
- Karen Rossmassler,
- Michelle E. Ramey,
- Allison A. Bauman,
- Victor Ozols,
- Shelby C. Bearrows,
- Gary Schoolnik,
- Gregory Dolganov,
- Benjamin Garcia,
- Emmanuel Musisi,
- William Worodria,
- Laurence Huang,
- J. Lucian Davis,
- Nhung V. Nguyen,
- Hung V. Nguyen,
- Anh T. V. Nguyen,
- Ha Phan,
- Carol Wilusz,
- Brendan K. Podell,
- N’ Dira Sanoussi,
- Bouke C. de Jong,
- Corinne S. Merle,
- Dissou Affolabi,
- Helen McIlleron,
- Maria Garcia-Cremades,
- Ekaterina Maidji,
- Franceen Eshun-Wilson,
- Brandon Aguilar-Rodriguez,
- Dhuvarakesh Karthikeyan,
- Khisimuzi Mdluli,
- Cathy Bansbach,
- Anne J. Lenaerts,
- Radojka M. Savic,
- Payam Nahid,
- Joshua J. Vásquez,
- Martin I. Voskuil
Affiliations
- Nicholas D. Walter
- Rocky Mountain Regional VA Medical Center
- Sarah E. M. Born
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- Gregory T. Robertson
- Consortium for Applied Microbial Metrics
- Matthew Reichlen
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- Christian Dide-Agossou
- Department of Epidemiology, Colorado School of Public Health
- Victoria A. Ektnitphong
- Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University
- Karen Rossmassler
- Rocky Mountain Regional VA Medical Center
- Michelle E. Ramey
- Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University
- Allison A. Bauman
- Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University
- Victor Ozols
- Rocky Mountain Regional VA Medical Center
- Shelby C. Bearrows
- Rocky Mountain Regional VA Medical Center
- Gary Schoolnik
- Division of Infectious Diseases and Geographic Medicine, Stanford University
- Gregory Dolganov
- Division of Infectious Diseases and Geographic Medicine, Stanford University
- Benjamin Garcia
- Integrated Center for Genes, Environment, and Health, National Jewish Health
- Emmanuel Musisi
- Infectious Disease Research Collaboration
- William Worodria
- Infectious Disease Research Collaboration
- Laurence Huang
- Division of Pulmonary and Critical Care Medicine, University of California San Francisco
- J. Lucian Davis
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Nhung V. Nguyen
- Vietnam National TB Programme/UCSF Research Collaboration Unit
- Hung V. Nguyen
- Vietnam National TB Programme/UCSF Research Collaboration Unit
- Anh T. V. Nguyen
- Vietnam National TB Programme/UCSF Research Collaboration Unit
- Ha Phan
- Vietnam National TB Programme/UCSF Research Collaboration Unit
- Carol Wilusz
- Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University
- Brendan K. Podell
- Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University
- N’ Dira Sanoussi
- Laboratoire de Référence des Mycobactéries
- Bouke C. de Jong
- Mycobacteriology Unit, Institute of Tropical Medicine
- Corinne S. Merle
- London School of Hygiene and Tropical Medicine
- Dissou Affolabi
- Laboratoire de Référence des Mycobactéries
- Helen McIlleron
- Division of Clinical Pharmacology, University of Cape Town
- Maria Garcia-Cremades
- Department of Bioengineering and Therapeutic Sciences, University of California San Francisco
- Ekaterina Maidji
- Division of Experimental Medicine, University of California San Francisco
- Franceen Eshun-Wilson
- Division of Experimental Medicine, University of California San Francisco
- Brandon Aguilar-Rodriguez
- Division of Experimental Medicine, University of California San Francisco
- Dhuvarakesh Karthikeyan
- Division of Experimental Medicine, University of California San Francisco
- Khisimuzi Mdluli
- Bill & Melinda Gates Medical Research Institute
- Cathy Bansbach
- Bill and Melinda Gates Foundation
- Anne J. Lenaerts
- Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University
- Radojka M. Savic
- Consortium for Applied Microbial Metrics
- Payam Nahid
- Consortium for Applied Microbial Metrics
- Joshua J. Vásquez
- Consortium for Applied Microbial Metrics
- Martin I. Voskuil
- Consortium for Applied Microbial Metrics
- DOI
- https://doi.org/10.1038/s41467-021-22833-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
It is unclear why different antibiotics vary in their ability to shorten treatment of tuberculosis. Here, the authors show that a measure based on ribosomal RNA synthesis in Mycobacterium tuberculosis correlates with treatment shortening in culture, in mice and in human studies.
