The phospholipid PI(3,4)P2 is an apical identity determinant

Álvaro Román-Fernández; Julie Roignot; Emma Sandilands; Marisa Nacke; Mohammed A. Mansour; Lynn McGarry; Emma Shanks; Keith E. Mostov; David M. Bryant

doi:10.1038/s41467-018-07464-8

Nature Communications (Nov 2018)

The phospholipid PI(3,4)P2 is an apical identity determinant

Álvaro Román-Fernández,
Julie Roignot,
Emma Sandilands,
Marisa Nacke,
Mohammed A. Mansour,
Lynn McGarry,
Emma Shanks,
Keith E. Mostov,
David M. Bryant

Affiliations

Álvaro Román-Fernández: Institute of Cancer Sciences, University of Glasgow
Julie Roignot: Department of Anatomy, University of California
Emma Sandilands: Institute of Cancer Sciences, University of Glasgow
Marisa Nacke: Institute of Cancer Sciences, University of Glasgow
Mohammed A. Mansour: Institute of Cancer Sciences, University of Glasgow
Lynn McGarry: The CRUK Beatson Institute
Emma Shanks: The CRUK Beatson Institute
Keith E. Mostov: Department of Anatomy, University of California
David M. Bryant: Institute of Cancer Sciences, University of Glasgow

DOI: https://doi.org/10.1038/s41467-018-07464-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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During de novo establishment of apical-basal polarity, a basolateral membrane must be converted into an apical delivery zone. Here, the authors use MDCK 3D cysts to uncover that the phospholipid PI(3,4)P2 is an apical membrane determinant.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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