Dopaminergic dynamics underlying sex-specific cocaine reward

Erin S. Calipari; Barbara Juarez; Carole Morel; Deena M. Walker; Michael E. Cahill; Efrain Ribeiro; Ciorana Roman-Ortiz; Charu Ramakrishnan; Karl Deisseroth; Ming-Hu Han; Eric J Nestler

doi:10.1038/ncomms13877

Nature Communications (Jan 2017)

Dopaminergic dynamics underlying sex-specific cocaine reward

Erin S. Calipari,
Barbara Juarez,
Carole Morel,
Deena M. Walker,
Michael E. Cahill,
Efrain Ribeiro,
Ciorana Roman-Ortiz,
Charu Ramakrishnan,
Karl Deisseroth,
Ming-Hu Han,
Eric J Nestler

Affiliations

Erin S. Calipari: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, New York 10029, USA
Barbara Juarez: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, New York 10029, USA
Carole Morel: Department of Pharmacological Sciences, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
Deena M. Walker: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, New York 10029, USA
Michael E. Cahill: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, New York 10029, USA
Efrain Ribeiro: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, New York 10029, USA
Ciorana Roman-Ortiz: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, New York 10029, USA
Charu Ramakrishnan: Department of Bioengineering, Stanford University
Karl Deisseroth: Department of Bioengineering, Stanford University
Ming-Hu Han: Department of Pharmacological Sciences, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
Eric J Nestler: Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, New York 10029, USA

DOI: https://doi.org/10.1038/ncomms13877
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Sex differences in reward processing are at present poorly understood. Calipari and Juarezet al. report oestrous cycle-dependent fluctuations in firing of VTA dopamine neurons that drive alterations in DAT function expressed in terminals in the NAc. These differences underlie enhanced cocaine reward processing during oestrus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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