Loss of the transcription factor MAFB limits β-cell derivation from human PSCs

Ronan Russell; Phichitpol P. Carnese; Thomas G. Hennings; Emily M. Walker; Holger A. Russ; Jennifer S. Liu; Simone Giacometti; Roland Stein; Matthias Hebrok

doi:10.1038/s41467-020-16550-9

Nature Communications (Jun 2020)

Loss of the transcription factor MAFB limits β-cell derivation from human PSCs

Ronan Russell,
Phichitpol P. Carnese,
Thomas G. Hennings,
Emily M. Walker,
Holger A. Russ,
Jennifer S. Liu,
Simone Giacometti,
Roland Stein,
Matthias Hebrok

Affiliations

Ronan Russell: UCSF Diabetes Center, University of California San Francisco
Phichitpol P. Carnese: UCSF Diabetes Center, University of California San Francisco
Thomas G. Hennings: UCSF Diabetes Center, University of California San Francisco
Emily M. Walker: Department of Molecular Physiology and Biophysics, Vanderbilt University
Holger A. Russ: UCSF Diabetes Center, University of California San Francisco
Jennifer S. Liu: UCSF Diabetes Center, University of California San Francisco
Simone Giacometti: UCSF Diabetes Center, University of California San Francisco
Roland Stein: Department of Molecular Physiology and Biophysics, Vanderbilt University
Matthias Hebrok: UCSF Diabetes Center, University of California San Francisco

DOI: https://doi.org/10.1038/s41467-020-16550-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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