Nature Communications (Oct 2022)
Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
- Yuqi Zhang,
- Yizeng Li,
- Keyata N. Thompson,
- Konstantin Stoletov,
- Qinling Yuan,
- Kaustav Bera,
- Se Jong Lee,
- Runchen Zhao,
- Alexander Kiepas,
- Yao Wang,
- Panagiotis Mistriotis,
- Selma A. Serra,
- John D. Lewis,
- Miguel A. Valverde,
- Stuart S. Martin,
- Sean X. Sun,
- Konstantinos Konstantopoulos
Affiliations
- Yuqi Zhang
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Yizeng Li
- Department of Biomedical Engineering, Binghamton University
- Keyata N. Thompson
- Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, University of Maryland School of Medicine
- Konstantin Stoletov
- Department of Oncology, University of Alberta
- Qinling Yuan
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Kaustav Bera
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Se Jong Lee
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Runchen Zhao
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Alexander Kiepas
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Yao Wang
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Panagiotis Mistriotis
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Selma A. Serra
- Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra
- John D. Lewis
- Department of Oncology, University of Alberta
- Miguel A. Valverde
- Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra
- Stuart S. Martin
- Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, University of Maryland School of Medicine
- Sean X. Sun
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- Konstantinos Konstantopoulos
- Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
- DOI
- https://doi.org/10.1038/s41467-022-33683-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. Here the authors show that the chloride ion channel SWELL1 and the ion exchanger NHE1 are preferentially enriched at the trailing and leading edges, respectively, of migrating cells and regulate cell volume to propel confined cells, favouring breast cancer cell extravasation and metastasis.
