Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

Van B. Lu; Juraj Rievaj; Elisabeth A. O’Flaherty; Christopher A. Smith; Ramona Pais; Luke A. Pattison; Gwen Tolhurst; Andrew B. Leiter; David C. Bulmer; Fiona M. Gribble; Frank Reimann

doi:10.1038/s41467-019-09045-9

Nature Communications (Mar 2019)

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

Van B. Lu,
Juraj Rievaj,
Elisabeth A. O’Flaherty,
Christopher A. Smith,
Ramona Pais,
Luke A. Pattison,
Gwen Tolhurst,
Andrew B. Leiter,
David C. Bulmer,
Fiona M. Gribble,
Frank Reimann

Affiliations

Van B. Lu: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
Juraj Rievaj: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
Elisabeth A. O’Flaherty: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
Christopher A. Smith: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
Ramona Pais: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
Luke A. Pattison: Department of Pharmacology, University of Cambridge
Gwen Tolhurst: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
Andrew B. Leiter: Department of Medicine, University of Massachusetts Medical School
David C. Bulmer: Department of Pharmacology, University of Cambridge
Fiona M. Gribble: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital
Frank Reimann: Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital

DOI: https://doi.org/10.1038/s41467-019-09045-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose neurons and enterocytes in a paracrine manner in vitro.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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