Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
Cristina P. Matos,
Zelal Adiguzel,
Yasemin Yildizhan,
Buse Cevatemre,
Tugba Bagci-Onder,
Ozge Cevik,
Patrique Nunes,
Liliana P. Ferreira,
Maria Deus Carvalho,
Débora L. Campos,
Fernando R. Pavan,
João Costa Pessoa,
Maria Helena Garcia,
Ana Isabel Tomaz,
Isabel Correia,
Ceyda Acilan
Affiliations
Cristina P. Matos
Centro de Química Estrutural, Instituto Superior Técnico, Departamento de Engenharia Quimica, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal
Zelal Adiguzel
TUBITAK, Marmara Research Center, Genetic Engineering and Biotechnology Institute, Gebze, Kocaeli, Turkey
Yasemin Yildizhan
TUBITAK, Marmara Research Center, Genetic Engineering and Biotechnology Institute, Gebze, Kocaeli, Turkey
Buse Cevatemre
Koc University Research Center for Translational Medicine (KUTTAM), Sariyer, Istanbul, Turkey
Tugba Bagci-Onder
Koc University Research Center for Translational Medicine (KUTTAM), Sariyer, Istanbul, Turkey; Koc University, Medical School, Sariyer, Istanbul, Turkey
Ozge Cevik
Adnan Menderes University, School of Medicine, Aydin, Turkey
Patrique Nunes
Centro de Química Estrutural, Instituto Superior Técnico, Departamento de Engenharia Quimica, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal
Liliana P. Ferreira
BioISI, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal; Department of Physics, University of Coimbra, 3004-516 Coimbra, Portugal
Maria Deus Carvalho
Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal
Débora L. Campos
Faculdade de Ciências Farmacêuticas, UNESP, C.P.582, Araraquara, SP 14801-902, Brazil
Fernando R. Pavan
Faculdade de Ciências Farmacêuticas, UNESP, C.P.582, Araraquara, SP 14801-902, Brazil
João Costa Pessoa
Centro de Química Estrutural, Instituto Superior Técnico, Departamento de Engenharia Quimica, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal
Maria Helena Garcia
Centro de Química Estrutural, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal
Ana Isabel Tomaz
Centro de Química Estrutural, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal
Isabel Correia
Centro de Química Estrutural, Instituto Superior Técnico, Departamento de Engenharia Quimica, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal; Corresponding author.
Ceyda Acilan
Koc University Research Center for Translational Medicine (KUTTAM), Sariyer, Istanbul, Turkey; Koc University, Medical School, Sariyer, Istanbul, Turkey; Corresponding author. Koc University, Medical School, Sariyer, Istanbul, Turkey.
This dataset is related to the research article entitled “May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?” [1]. It includes the characterization by UV–Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2−, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethyl)amine, and different aromatic bases (NN = 2,2′-bipyridine [Fe(L)(bipy)]PF6 (1), 1,10-phenanthroline [Fe(L)(phen)]PF6 (2), or a phenanthroline derivative co-ligand: [Fe(L)(amphen)]NO3 (3), [Fe(L)(amphen)]PF6 (3a), [Fe(L)(Clphen)]PF6 (4), [Fe(L)(epoxyphen)]PF6 (5) (where amphen = 1,10-phenanthroline-5-amine, epoxyphen = 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, Clphen = 5-chloro-1,10-phenanthroline), as well as [Fe(L)(EtOH)]NO3 (6), [Fe(phen)Cl3] (7) and [Fe(amphen)Cl3] (8). Data on their hydrolytic stability in physiological buffers is shown, as well as on their interaction with calf thymus DNA by spectroscopic tools. Additionally, the anticancer efficacy and the cellular death mechanisms activated in response to these drugs in HeLa, H1299 and MDA-MB-231 cells are provided. Keywords: Fe(III) complexes, Phenanthroline, Anticancer, Cytotoxicity, Genotoxicity
