Reproductive Biology and Endocrinology (Dec 2009)

Initiation of the expression of peroxisome proliferator - activated receptor gamma (PPAR gamma) in the rat ovary and the role of FSH

  • Sairam M Ram,
  • Long Mary J,
  • Komar Carolyn M

DOI
https://doi.org/10.1186/1477-7827-7-145
Journal volume & issue
Vol. 7, no. 1
p. 145

Abstract

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Abstract PPARgamma is highly expressed in granulosa cells by 23 days post-partum (pp) and is down-regulated in response to the LH surge. We tested the hypothesis that high levels of FSH during the neonatal period trigger the expression of PPARgamma. To determine when PPARgamma expression is initiated, ovaries were collected from neonatal rats. Messenger RNA for PPARgamma was undetectable on day 1, low from days 5-14, and increased by day 19 pp (p