Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

Yinan Jiang; Yichen Guo; Jinjin Hao; Rachael Guenter; Justin Lathia; Adam W. Beck; Reagan Hattaway; Douglas Hurst; Qiming Jane Wang; Yehe Liu; Qi Cao; Helen Krontiras; Herbert Chen; Roy Silverstein; Bin Ren

doi:10.1038/s42003-021-02308-6

Communications Biology (Jun 2021)

Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

Yinan Jiang,
Yichen Guo,
Jinjin Hao,
Rachael Guenter,
Justin Lathia,
Adam W. Beck,
Reagan Hattaway,
Douglas Hurst,
Qiming Jane Wang,
Yehe Liu,
Qi Cao,
Helen Krontiras,
Herbert Chen,
Roy Silverstein,
Bin Ren

Affiliations

Yinan Jiang: Department of Surgery, University of Alabama at Birmingham School of Medicine
Yichen Guo: Department of Surgery, University of Alabama at Birmingham School of Medicine
Jinjin Hao: Department of Surgery, University of Alabama at Birmingham School of Medicine
Rachael Guenter: Department of Surgery, University of Alabama at Birmingham School of Medicine
Justin Lathia: Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic
Adam W. Beck: Department of Surgery, University of Alabama at Birmingham School of Medicine
Reagan Hattaway: Department of Surgery, University of Alabama at Birmingham School of Medicine
Douglas Hurst: Department of Pathology, University of Alabama at Birmingham School of Medicine
Qiming Jane Wang: Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine
Yehe Liu: Department of Biomedical Engineering, Case Western Reserve University
Qi Cao: Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine
Helen Krontiras: Department of Surgery, University of Alabama at Birmingham School of Medicine
Herbert Chen: Department of Surgery, University of Alabama at Birmingham School of Medicine
Roy Silverstein: Department of Medicine, Medical College of Wisconsin, Milwaukee
Bin Ren: Department of Surgery, University of Alabama at Birmingham School of Medicine

DOI: https://doi.org/10.1038/s42003-021-02308-6
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Jiang, Guo, Hao et al. investigate the role of the tumour microenvironment in breast cancer stem cell regulation and identify an arteriolar niche in which BCSCs tended to be enriched in human estrogen receptor positive breast cancer. Here, BCSCs are found to interact with arteriolar endothelial cells through LPA/PKD-1 signalling-mediated arteriolar differentiation of ECs and self-renewal of BCSCs.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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