ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

Michele Proietti; Lisa Perruzza; Daniela Scribano; Giovanni Pellegrini; Rocco D’Antuono; Francesco Strati; Marco Raffaelli; Santiago F. Gonzalez; Marcus Thelen; Wolf-Dietrich Hardt; Emma Slack; Mauro Nicoletti; Fabio Grassi

doi:10.1038/s41467-018-08156-z

Nature Communications (Jan 2019)

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

Michele Proietti,
Lisa Perruzza,
Daniela Scribano,
Giovanni Pellegrini,
Rocco D’Antuono,
Francesco Strati,
Marco Raffaelli,
Santiago F. Gonzalez,
Marcus Thelen,
Wolf-Dietrich Hardt,
Emma Slack,
Mauro Nicoletti,
Fabio Grassi

Affiliations

Michele Proietti: Institute for Research in Biomedicine, Università della Svizzera Italiana
Lisa Perruzza: Institute for Research in Biomedicine, Università della Svizzera Italiana
Daniela Scribano: Department of Medical and Oral Sciences and Biotechnologies, University ‘‘Gabriele D’Annunzio’’, Via dei Vestini, Campus Universitario
Giovanni Pellegrini: Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich
Rocco D’Antuono: Institute for Research in Biomedicine, Università della Svizzera Italiana
Francesco Strati: Institute for Research in Biomedicine, Università della Svizzera Italiana
Marco Raffaelli: Institute for Research in Biomedicine, Università della Svizzera Italiana
Santiago F. Gonzalez: Institute for Research in Biomedicine, Università della Svizzera Italiana
Marcus Thelen: Institute for Research in Biomedicine, Università della Svizzera Italiana
Wolf-Dietrich Hardt: Institute of Microbiology, ETH Zürich
Emma Slack: Institute of Microbiology, ETH Zürich
Mauro Nicoletti: Department of Medical and Oral Sciences and Biotechnologies, University ‘‘Gabriele D’Annunzio’’, Via dei Vestini, Campus Universitario
Fabio Grassi: Institute for Research in Biomedicine, Università della Svizzera Italiana

DOI: https://doi.org/10.1038/s41467-018-08156-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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The generation of protective secretory IgA is a desired outcome of oral vaccination. Here, the authors show that the depletion of intestinal ATP significantly improves the production and response of high-affinity IgA against both live and inactivated oral vaccines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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