Outcome and prognosis of adjuvant chemotherapy of stage II colorectal cancer with lympatic invasion and stage III with N1 colorectal cancer

Abstract

Purpose: Guideline of stage II colon cancer chemotherapy is controversial issue. This study aims to assist in making proper guideline of stage II colorectal cancer chemotherapy. Methods: We retrospectively analyzed the medical records of 137 patients who had colorectal cancer surgery and chemotherapy at Sanggye Paik Hospital, Surgical Department from 2008 to February 2013. We analyzed disease-free survival rate (DFS), characteristics and relationship of stage II (II), stage II with lymphatic invasion (IIL), stage III with N1 (lymph mode involvement number under 3). Results: We found new metastasis in 23 patients (liver 11, lung 5, peritoneum 6, bone 1). There is no difference in DFS between II and IIL (P=0.064). But recurrence more frequently appeared with lymatic invasion group. There is no difference in DFS between IIL and III (P=0.083). But cancer stage had not effect to recurrence (P=0.153). In IIL patients, statistically difference did not be shown between oral and intravenous chemotherapy group (P=0.500). But chemotherapy completion group had higher DFS (P=0.001). Conclusion: Between II and IIL, DFS did not have difference but low P-value. In consideration of correlation analysis result and DFS between IIL and III, we think their prognosis is not same and completion of chemotherapy influence on good outcome in stage II with lymphatic invasion colon cancer.

Keywords

• colorectal cancer
• chemotherapy
• lymphatic invasion
• stage ii
• stage iii