Frontiers in Chemistry (Oct 2021)

Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

  • Ming Zhou,
  • Hui-Qi Gan,
  • Guo-Rong Chen,
  • Tony D James,
  • Tony D James,
  • Bin Zhang,
  • Qiang Hu,
  • Fugui Xu,
  • Xi-Le Hu,
  • Xiao-Peng He,
  • Yiyong Mai

DOI
https://doi.org/10.3389/fchem.2021.767847
Journal volume & issue
Vol. 9

Abstract

Read online

Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with Pseudomonas aeruginosa, a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.

Keywords