PLoS ONE (Jan 2013)

Association study confirmed susceptibility loci with keloid in the Chinese Han population.

  • Fei Zhu,
  • Baoyu Wu,
  • Ping Li,
  • Jianbo Wang,
  • Huayang Tang,
  • Ye Liu,
  • Xianbo Zuo,
  • Hui Cheng,
  • Yantao Ding,
  • Wen Wang,
  • Yujuan Zhai,
  • Fangfang Qian,
  • Wenju Wang,
  • Xiangfeng Yuan,
  • Jing Wang,
  • Weiwei Ha,
  • Junsheng Hou,
  • Fusheng Zhou,
  • Yin Wang,
  • Jinping Gao,
  • Yujun Sheng,
  • Liangdan Sun,
  • Jianjun Liu,
  • Sen Yang,
  • Xuejun Zhang

DOI
https://doi.org/10.1371/journal.pone.0062377
Journal volume & issue
Vol. 8, no. 5
p. e62377

Abstract

Read online

Keloid is benign fibroproliferative dermal tumors with unknown etiology. Recently, a genome-wide association study (GWAS) in Japanese population has identified 3 susceptibility loci (rs873549 at 1q41, rs940187 and rs1511412 at 3q22.3, rs8032158 at 15p21.3) for keloid. In order to examine whether these susceptibility loci are associated with keloid in the Chinese Han population, twelve previously reported SNPs were selected for replication in 714 cases and 2,944 controls by using Sequenom MassArray system. We found three SNPs in two regions showed significant association with keloid in the Chinese Han population: 1q41 (rs873549, P = 3.03×10(-33), OR = 2.05, 95% CI: 1.82-2.31 and rs1442440, P = 9.85×10(-18), OR = 0.56, 95% CI: 0.49-0.64, respectively) and 15q21.3 (rs2271289 located in NEDD4, P = 1.02×10(-11), OR = 0.66, 95% CI: 0.58-0.74). We also detected one risk haplotype AG (P = 1.36×10(-31), OR = 2.02) and two protective haplotypes of GA and AA (GA, P = 1.94×10(-19), OR = 0.53, AA, P = 0.00043, OR = 0.78, respectively) from the two SNPs (rs873549 and rs1442440). Our study confirmed two previously reported loci 1q41 and 15q21.3 for keloid in the Chinese Han population, which suggested the common genetic factor predisposing to the development of keloid shared by the Chinese Han and Japanese populations.