Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

Abstract

To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host. Keywords: Natural products, Synthetic biology, Aromatic polyketides, CRISPR/Cas9, Polyketide, Production platform in eukaryotes, Metabolic engineering, Biotechnology