Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles

Abstract

Compounds containing stereocenters bearing -CF3 groups, especially in proximity of heteroatoms, are of great interest for drug and agrochemicals development. Here, the authors report a nickel-catalyzed Hiyama cross-coupling methodology for the asymmetric synthesis of valuable alpha-trifluoromethyl alcohols and ethers.