Microbiome (Dec 2021)

Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing

  • Jongoh Shin,
  • Jung-Ran Noh,
  • Donghui Choe,
  • Namil Lee,
  • Yoseb Song,
  • Suhyung Cho,
  • Eun-Jung Kang,
  • Min-Jeong Go,
  • Seok Kyun Ha,
  • Dong-Ho Chang,
  • Jae-Hoon Kim,
  • Yong-Hoon Kim,
  • Kyoung-Shim Kim,
  • Haiyoung Jung,
  • Myung Hee Kim,
  • Bong-Hyun Sung,
  • Seung-Goo Lee,
  • Dae-Hee Lee,
  • Byoung-Chan Kim,
  • Chul-Ho Lee,
  • Byung-Kwan Cho

DOI
https://doi.org/10.1186/s40168-021-01189-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 19

Abstract

Read online

Abstract Background The gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and faecal microbiota transplantation, have been applied to alter the gut microbiome and promote healthy ageing. Nevertheless, prolongation of the health span of aged mice by remodelling the gut microbiome remains challenging. Results Here, we report the changes in gut microbial communities and their functions in mouse models during ageing and three rejuvenation procedures including co-housing, serum-injection and parabiosis. Our results showed that the compositional structure and gene abundance of the intestinal microbiota changed dynamically during the ageing process. Through the three rejuvenation procedures, we observed that the microbial community and intestinal immunity of aged mice were comparable to those of young mice. The results of metagenomic data analysis underscore the importance of the high abundance of Akkermansia and the butyrate biosynthesis pathway in the rejuvenated mouse group. Furthermore, oral administration of Akkermansia sufficiently ameliorated the senescence-related phenotype in the intestinal systems in aged mice and extended the health span, as evidenced by the frailty index and restoration of muscle atrophy. Conclusions In conclusion, the changes in key microbial communities and their functions during ageing and three rejuvenation procedures, and the increase in the healthy lifespan of aged mice by oral administration of Akkermansia. Our results provide a rationale for developing therapeutic strategies to achieve healthy active ageing. Video abstract

Keywords