Nature Communications (Jul 2020)
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
- Jakob Seidlitz,
- Ajay Nadig,
- Siyuan Liu,
- Richard A. I. Bethlehem,
- Petra E. Vértes,
- Sarah E. Morgan,
- František Váša,
- Rafael Romero-Garcia,
- François M. Lalonde,
- Liv S. Clasen,
- Jonathan D. Blumenthal,
- Casey Paquola,
- Boris Bernhardt,
- Konrad Wagstyl,
- Damon Polioudakis,
- Luis de la Torre-Ubieta,
- Daniel H. Geschwind,
- Joan C. Han,
- Nancy R. Lee,
- Declan G. Murphy,
- Edward T. Bullmore,
- Armin Raznahan
Affiliations
- Jakob Seidlitz
- Developmental Neurogenomics Unit, National Institute of Mental Health
- Ajay Nadig
- Developmental Neurogenomics Unit, National Institute of Mental Health
- Siyuan Liu
- Developmental Neurogenomics Unit, National Institute of Mental Health
- Richard A. I. Bethlehem
- Department of Psychiatry, University of Cambridge
- Petra E. Vértes
- Department of Psychiatry, University of Cambridge
- Sarah E. Morgan
- Department of Psychiatry, University of Cambridge
- František Váša
- Department of Psychiatry, University of Cambridge
- Rafael Romero-Garcia
- Department of Psychiatry, University of Cambridge
- François M. Lalonde
- Developmental Neurogenomics Unit, National Institute of Mental Health
- Liv S. Clasen
- Developmental Neurogenomics Unit, National Institute of Mental Health
- Jonathan D. Blumenthal
- Developmental Neurogenomics Unit, National Institute of Mental Health
- Casey Paquola
- McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital
- Boris Bernhardt
- McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital
- Konrad Wagstyl
- Department of Psychiatry, University of Cambridge
- Damon Polioudakis
- Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, UCLA
- Luis de la Torre-Ubieta
- Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, UCLA
- Daniel H. Geschwind
- Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, UCLA
- Joan C. Han
- Departments of Pediatrics and Physiology, University of Tennessee Health Science Center and Le Bonheur Children’s Foundation Research Institute
- Nancy R. Lee
- Department of Psychology, Drexel University
- Declan G. Murphy
- Institute of Psychiatry, King’s College London
- Edward T. Bullmore
- Department of Psychiatry, University of Cambridge
- Armin Raznahan
- Developmental Neurogenomics Unit, National Institute of Mental Health
- DOI
- https://doi.org/10.1038/s41467-020-17051-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.
