Case Report: Allogenic Simple Limbal Epithelial Transplantation From a Human Leukocyte Antigen-Matched Living Related Donor to Treat Bilateral Corneal Chemical Burns Post Laser-Assisted in situ Keratomileusis

Yuh-Shin Chang; Yuh-Shin Chang; Tsung-Yueh Chan; Tsung-Yueh Chan; Ren-Long Jan; Ren-Long Jan; Sung-Huei Tseng; Sung-Huei Tseng

doi:10.3389/fmed.2022.849791

Frontiers in Medicine (Feb 2022)

Case Report: Allogenic Simple Limbal Epithelial Transplantation From a Human Leukocyte Antigen-Matched Living Related Donor to Treat Bilateral Corneal Chemical Burns Post Laser-Assisted in situ Keratomileusis

Yuh-Shin Chang,
Yuh-Shin Chang,
Tsung-Yueh Chan,
Tsung-Yueh Chan,
Ren-Long Jan,
Ren-Long Jan,
Sung-Huei Tseng,
Sung-Huei Tseng

Affiliations

Yuh-Shin Chang: Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan
Yuh-Shin Chang: Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan
Tsung-Yueh Chan: Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan
Tsung-Yueh Chan: Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
Ren-Long Jan: Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan
Ren-Long Jan: Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan, Taiwan
Sung-Huei Tseng: Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan
Sung-Huei Tseng: Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

DOI: https://doi.org/10.3389/fmed.2022.849791
Journal volume & issue: Vol. 9

Abstract

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A 35-year-old woman who had undergone laser-assisted in situ keratomileusis in both eyes experienced bilateral total limbal stem cell deficiency (LSCD) due to chemical burns. Due to bilateral severe LSCD, allogenic simple limbal epithelial transplantation (SLET) from a human leukocyte antigen (HLA)-matched living related donor was the first choice of treatment for her left eye. We report the first case of HLA or ABO matching living related allogenic SLET for permanent restoration of the cornea for bilateral LSCD treatment. Our ABO-HLA-matched living related allogenic SLET alleviation of the systemic immunosuppressant to topical corticosteroids alone. It also came the limitations of prolonged systemic immunosuppressant usage in conjunctival-limbal allografts and keratolimbal allograft.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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