Recent advances in surface plasmon resonance imaging: detection speed, sensitivity, and portability
Zeng Youjun,
Hu Rui,
Wang Lei,
Gu Dayong,
He Jianan,
Wu Shu-Yuen,
Ho Ho-Pui,
Li Xuejin,
Qu Junle,
Gao Bruce Zhi,
Shao Yonghong
Affiliations
Zeng Youjun
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China
Hu Rui
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China
Wang Lei
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China
Gu Dayong
Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen 518033, China
He Jianan
Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen 518033, China
Wu Shu-Yuen
Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong
Ho Ho-Pui
Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong
Li Xuejin
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China
Qu Junle
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China
Gao Bruce Zhi
Department of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA
Shao Yonghong
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China, Tel.: +86-135-2884-9905
Surface plasmon resonance (SPR) biosensor is a powerful tool for studying the kinetics of biomolecular interactions because they offer unique real-time and label-free measurement capabilities with high detection sensitivity. In the past two decades, SPR technology has been successfully commercialized and its performance has continuously been improved with lots of engineering efforts. In this review, we describe the recent advances in SPR technologies. The developments of SPR technologies focusing on detection speed, sensitivity, and portability are discussed in details. The incorporation of imaging techniques into SPR sensing is emphasized. In addition, our SPR imaging biosensors based on the scanning of wavelength by a solid-state tunable wavelength filter are highlighted. Finally, significant advances of the vast developments in nanotechnology-associated SPR sensing for sensitivity enhancements are also reviewed. It is hoped that this review will provide some insights for researchers who are interested in SPR sensing, and help them develop SPR sensors with better sensitivity and higher throughput.
