Comparison of the effect of bupivacaine–fentanyl compared bupivacaine–sufentanil in spinal anaesthetics in pregnant women in Zanjan, Iran

Abstract

Background: Labour pain is the most severe pain experienced by a mother during her lifetime. This study aims to encourage normal delivery, reduce caesarean section, and morbidity by comparing two fentanyl–bupivacaine and sufentanil–bupivacaine combination as spinal anaesthetics of the mothers who referred to Ayatollah Mousavi Hospital in Zanjan in the active phase of delivery. Materials and Methods: This study was performed on 90 pregnant women with active phase of labour who were divided into three groups. The first group received 50 μg fentanyl and 2.5 mg bupivacaine and the second group received 5 μg sufentanil and 2.5 μg bupivacaine by spinal injection and the third group received no intervention. The severity of analgesia and maternal and neonatal outcomes were recorded. To compare the data, ANOVA, t-test and Chi-square test were used. Results: Our study showed that the duration, the first and second stage of labour, did not show significant difference between three groups (P > 0.05). Sufentanil has a faster return pain duration (P = 0.37). Patients in Group A had more severe pain (3.93 vs. 4.73,P = 0.001). Return the sense was significantly longer for fentanyl (P = 0.001). In sufentanil group, 40% were in T8–T10 level, while in fentanyl use group, 20% were categorized in this range. Conclusion: The present study reported that the use of fentanyl or sufentanil in combination with bupivacaine for spinal analgesia as a low-risk method for controlling labour pain, although it seems that the combination of sufentanil–bupivacaine is more effective.

Keywords

• Bupivacaine
• fentanyl
• normal vaginal delivery
• spinal analgesia
• sufentanil