BMC Psychiatry (Apr 2011)

Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD

  • Bhat Venkataramana,
  • Grizenko Natalie,
  • Lee James,
  • Sengupta Sarojini,
  • Polotskaia Anna,
  • Joober Ridha

DOI
https://doi.org/10.1186/1471-244X-11-70
Journal volume & issue
Vol. 11, no. 1
p. 70

Abstract

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Abstract Background The desired (therapeutic) and undesired (side) effects of methylphenidate might have underlying correlations. The aim of this study was to explore the strength and the possible sources of these correlations. Methods One hundred and fifty-seven children with ADHD (6-12 years) were administered placebo and methylphenidate (0.5 mg/kg in a divided b.i.d. dose), each for a one-week period, in a double-blind, crossover trial. Therapeutic response was assessed using the Conners' Global Index for parents (CGI-Parents) and teachers (CGI-Teachers), while side effects were assessed using the Barkley Side Effects Rating Scale (SERS). Results The side effect profile as assessed by the SERS was similar to that of previous studies with insomnia, decreased appetite, and headaches showing significant treatment effects (p Conclusion The greater "mood/anxiety" side effects on methylphenidate and placebo, the less the parents observe improvement of their children while treated with methylphenidate. This suggests that the correlations between "mood/anxiety" side effects and poor response to treatment may be driven by observer effects rather than biological commonalities between therapeutic and side effects of methylphenidate.