Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

Xiaojing Nie; Xueyan Zhang; Xueyan Zhang; Baozhen Lei; Baozhen Lei; Yonghua Shi; Jingxin Yang; Jingxin Yang

doi:10.3389/fbioe.2022.842706

Frontiers in Bioengineering and Biotechnology (Mar 2022)

Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

Xiaojing Nie,
Xueyan Zhang,
Xueyan Zhang,
Baozhen Lei,
Baozhen Lei,
Yonghua Shi,
Jingxin Yang,
Jingxin Yang

Affiliations

Xiaojing Nie: Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, China
Xueyan Zhang: Beijing Engineering Research Center of Smart Mechanical Innovation Design Service, Beijing Union University, Beijing, China
Xueyan Zhang: College of Robotics, Beijing Union University, Beijing, China
Baozhen Lei: Beijing Engineering Research Center of Smart Mechanical Innovation Design Service, Beijing Union University, Beijing, China
Baozhen Lei: College of Robotics, Beijing Union University, Beijing, China
Yonghua Shi: Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, China
Jingxin Yang: Beijing Engineering Research Center of Smart Mechanical Innovation Design Service, Beijing Union University, Beijing, China
Jingxin Yang: College of Robotics, Beijing Union University, Beijing, China

DOI: https://doi.org/10.3389/fbioe.2022.842706
Journal volume & issue: Vol. 10

Abstract

Read online

Despite magnesium based metal materials are widely used in bone defect repair, there are still various deficiencies, and their properties need to be optimized. Composites synthesized with magnesium based metal as matrix are the research hotspot, and the host immune response after biomaterial implantation is very important for bone binding. By studying the immunoregulation of bone biomaterials, it can regulate the immune response in the process of osteogenesis and create a good local immune microenvironment, which is conducive to biomaterials to reduce inflammatory response and promote good bone binding. This article introduces the osteogenic mechanism of magnesium based metal materials and its regulation on bone immune microenvironment in detail.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

About the journal

Abstract

Keywords