Positive correlation between fasting plasma glucagon and serum C-peptide in Japanese patients with diabetes

Yoshiya Hosokawa; Junji Kozawa; Hitoshi Nishizawa; Dan Kawamori; Norikazu Maeda; Michio Otsuki; Taka-aki Matsuoka; Hiromi Iwahashi; Iichiro Shimomura

Heliyon (May 2019)

Positive correlation between fasting plasma glucagon and serum C-peptide in Japanese patients with diabetes

Yoshiya Hosokawa,
Junji Kozawa,
Hitoshi Nishizawa,
Dan Kawamori,
Norikazu Maeda,
Michio Otsuki,
Taka-aki Matsuoka,
Hiromi Iwahashi,
Iichiro Shimomura

Affiliations

Yoshiya Hosokawa: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Corresponding author.
Junji Kozawa: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Hitoshi Nishizawa: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Dan Kawamori: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Medical Education Center, Faculty of Medicine, Osaka University, Suita, Osaka Japan
Norikazu Maeda: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Michio Otsuki: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Taka-aki Matsuoka: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Hiromi Iwahashi: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Iichiro Shimomura: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

Journal volume & issue: Vol. 5, no. 5
p. e01715

Abstract

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Aims: Glucagon plays pivotal roles in systemic glucose homeostasis mainly by promoting hepatic glucose output. Using a sandwich enzyme-linked immunosorbent assay (ELISA), we evaluated fasting plasma glucagon levels in hospitalized patients with type 1 or type 2 diabetes, and assessed the relationships between glucagon levels and various clinical parameters. Methods: We enrolled adult Japanese diabetes patients admitted to Osaka University Medical Hospital for glycemic control between July 2017 and May 2018 in this study. After patients had fasted for 12 h, blood samples were obtained and plasma glucagon levels were measured using a sandwich ELISA. Results: Total 107 patients participated in the study. The mean fasting plasma glucagon level of patients with acute onset type 1 diabetes was significantly lower than that of patients with type 2 diabetes (p < 0.05). Plasma glucagon levels were not significantly correlated with plasma glucose levels in patients with type 1 diabetes or in patients with type 2 diabetes. Multiple regression analysis indicated that fasting glucagon levels were independently and significantly correlated with fasting serum C-peptide levels in patients with type 2 diabetes. Conclusions: Our results suggest that insulin and glucagon secretion are balanced in the fasting state in patients with type 2 diabetes.

Metabolism

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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