Developmental activities of the complement pathway in migrating neurons

Anna Gorelik; Tamar Sapir; Rebecca Haffner-Krausz; Tsviya Olender; Trent M. Woodruff; Orly Reiner

doi:10.1038/ncomms15096

Nature Communications (May 2017)

Developmental activities of the complement pathway in migrating neurons

Anna Gorelik,
Tamar Sapir,
Rebecca Haffner-Krausz,
Tsviya Olender,
Trent M. Woodruff,
Orly Reiner

Affiliations

Anna Gorelik: Department of Molecular Genetics, Weizmann Institute of Science
Tamar Sapir: Department of Molecular Genetics, Weizmann Institute of Science
Rebecca Haffner-Krausz: Department of Veterinary Resources, Weizmann Institute of Science
Tsviya Olender: Department of Molecular Genetics, Weizmann Institute of Science
Trent M. Woodruff: School of Biomedical Sciences, University of Queensland, BNE
Orly Reiner: Department of Molecular Genetics, Weizmann Institute of Science

DOI: https://doi.org/10.1038/ncomms15096
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Emerging evidence suggests that immune molecules play an important role in regulating brain development. Goreliket al. show that molecules in the lectin arm of the complement pathway are expressed in the developing mouse cortex, and regulate radial migration of excitatory neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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