Journal of Allergy and Clinical Immunology: Global (Feb 2024)
The ability of biomarkers to assess the severity of atopic dermatitis
- Takeshi Nakahara, MD, PhD,
- Daisuke Onozuka, PhD,
- Satoshi Nunomura, PhD,
- Hidehisa Saeki, MD, PhD,
- Motoi Takenaka, MD, PhD,
- Mai Matsumoto, MD, PhD,
- Yoko Kataoka, MD,
- Rai Fujimoto, MD, PhD,
- Sakae Kaneko, MD, PhD,
- Eishin Morita, MD, PhD,
- Akio Tanaka, MD, PhD,
- Ryo Saito, MD, PhD,
- Tatsuro Okano, MD, PhD,
- Tomomitsu Miyagaki, MD, PhD,
- Natsuko Aoki, MD, PhD,
- Kimiko Nakajima, MD, PhD,
- Susumu Ichiyama, MD, PhD,
- Makiko Kido-Nakahara, MD, PhD,
- Kyoko Tonomura, MD, PhD,
- Yukinobu Nakagawa, MD, PhD,
- Risa Tamagawa-Mineoka, MD, PhD,
- Koji Masuda, MD, PhD,
- Takuya Takeichi, MD, PhD,
- Masashi Akiyama, MD, PhD,
- Yozo Ishiuji, MD, PhD,
- Michie Katsuta, MD, PhD,
- Yuki Kinoshita, MD, PhD,
- Chiharu Tateishi, MD, PhD,
- Aya Yamamoto, MD, PhD,
- Akimichi Morita, MD, PhD,
- Haruna Matsuda-Hirose, MD, PhD,
- Yutaka Hatano, MD, PhD,
- Hiroshi Kawasaki, MD, PhD,
- Ayano Fukushima-Nomura, MD,
- Mamitaro Ohtsuki, MD, PhD,
- Koji Kamiya, MD, PhD,
- Yudai Kabata, MD, PhD,
- Riichiro Abe, MD, PhD,
- Hiroshi Mitsui, MD, PhD,
- Tatsuyoshi Kawamura, MD, PhD,
- Gaku Tsuji, MD, PhD,
- Norito Katoh, MD, PhD,
- Masutaka Furue, MD, PhD,
- Kenji Izuhara, MD, PhD
Affiliations
- Takeshi Nakahara, MD, PhD
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Daisuke Onozuka, PhD
- Department of Oral Microbe Control, Graduate School of Medicine, Osaka University, Osaka, Japan
- Satoshi Nunomura, PhD
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
- Hidehisa Saeki, MD, PhD
- Department of Dermatology, Nippon Medical School, Tokyo, Japan
- Motoi Takenaka, MD, PhD
- Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
- Mai Matsumoto, MD, PhD
- Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
- Yoko Kataoka, MD
- Department of Dermatology, Osaka Habikino Medical Center, Osaka, Japan
- Rai Fujimoto, MD, PhD
- Department of Dermatology, Osaka Habikino Medical Center, Osaka, Japan
- Sakae Kaneko, MD, PhD
- Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan
- Eishin Morita, MD, PhD
- Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan
- Akio Tanaka, MD, PhD
- Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
- Ryo Saito, MD, PhD
- Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
- Tatsuro Okano, MD, PhD
- Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, Japan
- Tomomitsu Miyagaki, MD, PhD
- Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, Japan
- Natsuko Aoki, MD, PhD
- Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan
- Kimiko Nakajima, MD, PhD
- Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan
- Susumu Ichiyama, MD, PhD
- Department of Dermatology, Nippon Medical School, Tokyo, Japan
- Makiko Kido-Nakahara, MD, PhD
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Kyoko Tonomura, MD, PhD
- Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
- Yukinobu Nakagawa, MD, PhD
- Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
- Risa Tamagawa-Mineoka, MD, PhD
- Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Koji Masuda, MD, PhD
- Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Takuya Takeichi, MD, PhD
- Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, Japan
- Masashi Akiyama, MD, PhD
- Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, Japan
- Yozo Ishiuji, MD, PhD
- Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
- Michie Katsuta, MD, PhD
- Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
- Yuki Kinoshita, MD, PhD
- Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
- Chiharu Tateishi, MD, PhD
- Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
- Aya Yamamoto, MD, PhD
- Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
- Akimichi Morita, MD, PhD
- Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
- Haruna Matsuda-Hirose, MD, PhD
- Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan
- Yutaka Hatano, MD, PhD
- Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan
- Hiroshi Kawasaki, MD, PhD
- Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan
- Ayano Fukushima-Nomura, MD
- Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan
- Mamitaro Ohtsuki, MD, PhD
- Department of Dermatology, Jichi Medical University, Tochigi, Japan
- Koji Kamiya, MD, PhD
- Department of Dermatology, Jichi Medical University, Tochigi, Japan
- Yudai Kabata, MD, PhD
- Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Riichiro Abe, MD, PhD
- Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Hiroshi Mitsui, MD, PhD
- Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
- Tatsuyoshi Kawamura, MD, PhD
- Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
- Gaku Tsuji, MD, PhD
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Norito Katoh, MD, PhD
- Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Masutaka Furue, MD, PhD
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
- Kenji Izuhara, MD, PhD
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan; Corresponding author: Kenji Izuhara, MD, PhD, Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5-1-1, Nabeshima, Saga, 849-8501, Japan.
- Journal volume & issue
-
Vol. 3,
no. 1
p. 100175
Abstract
Background: To develop precision medicine for atopic dermatitis (AD), it is critical to establish relevant biomarkers. However, the characteristics of various biomarkers have not been fully understood. We previously carried out the Biomarkers to Predict Clinical Improvement of AD in Patients Treated with Dupilumab (B-PAD) study, a comprehensive nationwide study in Japan, to explore biomarkers for AD. Objective: The aim of this study is to find biomarkers associated with objective and subjective clinical findings in patients with moderate-to-severe AD based on the B-PAD study and to identify biomarkers sensitive enough to assess the severity of AD. Methods: We performed the B-PAD study as a consortium composed of 19 medical facilities in Japan, enrolling 110 patients with moderate-to-severe AD. We evaluated the Eczema Area and Severity Index (EASI) for objective assessment as well as the Patient-Oriented Eczema Measure (POEM) and a numeric rating scale for pruritus (pruritis-NRS) for subjective assessment, measuring 19 biomarkers at baseline. Results: We found that 12, 6, and 7 biomarkers showed significant and positive associations with the EASI, POEM, and pruritis-NRS, respectively. Most of the biomarkers associated with either the POEM or the pruritis-NRS were included among the biomarkers associated with EASI. Of the biomarkers examined, CCL26/eotaxin-3 and SCCA2 were the most capable of assessing severity for EASI, as shown by the 2 kinds of receiver operating characteristic analyses, respectively, whereas lactate dehydrogenase was the best for both the POEM and pruritis-NRS, again using the 2 analyses. Conclusion: We found biomarkers associated with the EASI, POEM, and pruritis-NRS, respectively, based on the B-PAD study. Moreover, we identified CCL26/eotaxin-3 and/or SCCA2 as the biomarkers having the greatest ability to assess severity in the EASI; lactate dehydrogenase did the same for the POEM and pruritis-NRS. These findings will be useful in treating patients with moderate-to-severe AD.
