PLoS Genetics (Jan 2012)

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

  • Cynthia Sandor,
  • Wanbo Li,
  • Wouter Coppieters,
  • Tom Druet,
  • Carole Charlier,
  • Michel Georges

DOI
https://doi.org/10.1371/journal.pgen.1002854
Journal volume & issue
Vol. 8, no. 7
p. e1002854

Abstract

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We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.