COVID-19 Biomarkers Comparison: Children, Adults and Elders
Ionut Dragos Capraru,
Dan Dumitru Vulcanescu,
Iulia Cristina Bagiu,
Florin George Horhat,
Irina Maria Popescu,
Luminita Mirela Baditoiu,
Delia Muntean,
Monica Licker,
Matilda Radulescu,
Ion Cristian Mot,
Mircea Mihai Diaconu,
Catalin Marian
Affiliations
Ionut Dragos Capraru
Department of Epidemiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Dan Dumitru Vulcanescu
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Iulia Cristina Bagiu
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Florin George Horhat
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Irina Maria Popescu
Department of Epidemiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Luminita Mirela Baditoiu
Department of Epidemiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Delia Muntean
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Monica Licker
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Matilda Radulescu
Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Ion Cristian Mot
ENT Department, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
Mircea Mihai Diaconu
Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Catalin Marian
Department of Biochemistry, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timisoara, Romania
Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. Materials and Methods: this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. Results: 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. Conclusions: CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.
