Anticancer potentiality of green synthesized Mg-Co ferrites nanoparticles against human breast cancer MCF-7 cells

Abstract

Inherent magnetic features of engineered nanomaterials are quite important parameters for biomedical applications and cancer treatments. In this study, cobalt ferrite (CF-NPs) and magnesium-cobalt ferrite (MCF-NPs) magnetic nanoparticles were synthesized by aqueous extract of turmeric, characterized by various instruments, and utilized for anticancer activity. These are characterized with TG-DTG, XRD, SEM, BET, FTIR, and UV–Vis sophisticated techniques. The results revealed that they have inverse cubic spinel structure, optically active and nanoscale spherical morphology. The particle size was calculated by the Scherrer formula and was found to be 24.78 nm for CF-NPs and 27.48 nm for MCF-NPs, respectively. Moreover, MTT method was used to find out anticancer activity of the fabricated CF-NPs and MCF-NPs using the human breast cancer cells (MCF-7) and data discloses that cytotoxicity effects of CF-NPs are higher than MCF-NPs, and dose dependent. At high dose (100 μg/ml), CF-NPs shows 45.76% and 61.57% in CF-NPs and MCF-NPs cell viability, respectively. Similarly, cellular ROS generation was found to be higher in CF-NPs (183 %) as compared to MCF-NPs (159% in at 100 μg/ml). By the obtained results it can be claimed that ferrites will be useful model for cancer treatments if they are explored at advance level.

Keywords

• Ferrites
• Crystal structure
• Morphology
• Optical
• Cytotoxicity
• ROS