Nature Communications (Jan 2018)
GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
- Yusaku Iwasaki,
- Mio Sendo,
- Katsuya Dezaki,
- Tohru Hira,
- Takehiro Sato,
- Masanori Nakata,
- Chayon Goswami,
- Ryohei Aoki,
- Takeshi Arai,
- Parmila Kumari,
- Masaki Hayakawa,
- Chiaki Masuda,
- Takashi Okada,
- Hiroshi Hara,
- Daniel J. Drucker,
- Yuichiro Yamada,
- Masaaki Tokuda,
- Toshihiko Yada
Affiliations
- Yusaku Iwasaki
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Mio Sendo
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Katsuya Dezaki
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Tohru Hira
- Research Faculty of Agriculture, Hokkaido University
- Takehiro Sato
- Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine
- Masanori Nakata
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Chayon Goswami
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Ryohei Aoki
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Takeshi Arai
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Parmila Kumari
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- Masaki Hayakawa
- Graduate School of Agriculture, Hokkaido University
- Chiaki Masuda
- Department of Biochemistry and Molecular Biology, Nippon Medical School
- Takashi Okada
- Department of Biochemistry and Molecular Biology, Nippon Medical School
- Hiroshi Hara
- Research Faculty of Agriculture, Hokkaido University
- Daniel J. Drucker
- Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital
- Yuichiro Yamada
- Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine
- Masaaki Tokuda
- Faculty of Medicine, Department of Cell Physiology, Kagawa University
- Toshihiko Yada
- Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-02488-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
The sweetener D-allulose has beneficial metabolic effects in animal models, but its mechanism of action was unclear. Here the authors report that D-allulose triggers GLP-1 release in the gut and GLP-1R signaling on vagal afferents, counteracting arrhythmic overeating, obesity and diabetes.
