Quorum sensing inhibitors of bacteria Streptococcus pneumoniae

Abstract

The scientific review systematizes information on LuxS/AI-2 and ComABCDE quorum sensing systems of bacteria Streptococcus pneumoniae. It is emphasized that biofilms of bacteria Streptococcus pneumoniae are one of the mechanisms of antibiotic resistance and a source of highly invasive bacterial clones. A brief description of 5-azacytidine, sinefungin and pyrimidinedione, which have a specific anti-biofilm effect, is given.

Keywords

• quorum sensing
• Streptococcus pneumoniae
• quorum sensing inhibitors