Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder d

Adeyinka Aina; Manish Gupta; Yamina Boukari; Andrew Morris; Nashiru Billa; Stephen Doughty

doi:10.1016/j.jsps.2015.03.015

Saudi Pharmaceutical Journal (Mar 2016)

Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder d

Adeyinka Aina,
Manish Gupta,
Yamina Boukari,
Andrew Morris,
Nashiru Billa,
Stephen Doughty

Affiliations

Adeyinka Aina: Department of Mathematics and Natural Science, American University of Iraq, Kirkuk Main Road, Raparin, Sulaimani, Iraq
Manish Gupta: Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
Yamina Boukari: Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
Andrew Morris: Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
Nashiru Billa: Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
Stephen Doughty: Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia

DOI: https://doi.org/10.1016/j.jsps.2015.03.015
Journal volume & issue: Vol. 24, no. 2
pp. 227 – 231

Abstract

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The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture.

Published in Saudi Pharmaceutical Journal

ISSN: 1319-0164 (Print); 2213-7475 (Online)
Publisher: Springer
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://link.springer.com/journal/44446

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