PLoS ONE (Jan 2018)

Association between sleep-disordered breathing and breast cancer aggressiveness.

  • Francisco Campos-Rodriguez,
  • Antonio Cruz-Medina,
  • Maria Jose Selma,
  • Maria Rodriguez-de-la-Borbolla-Artacho,
  • Adrian Sanchez-Vega,
  • Francisco Ripoll-Orts,
  • Carmen V Almeida-Gonzalez,
  • Miguel Angel Martinez-Garcia

DOI
https://doi.org/10.1371/journal.pone.0207591
Journal volume & issue
Vol. 13, no. 11
p. e0207591

Abstract

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BACKGROUND:Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast cancer (BC) aggressiveness. METHODS:83 consecutive women 28% and Ki6728% and Ki67<29% (51.2% vs 52.3%, p = 0.90), HR- and HR+ (58.3% vs 49.1%, p = 0.47), NHG categories (p = 0.89), different tumor stages (p = 0.71), or molecular subtypes (p = 0.73). These results did not change when the ODI4 was used instead of the AHI. CONCLUSION:Our results do not support an association between the presence or severity of SDB and BC aggressiveness.