Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Abstract

Song et al. use transgenic mice lacking the Na/H exchanger specifically in microglia to show that microglial oxidative phosphorylation plays a key role in post-stroke brain tissue repair and cognitive recovery. Their data is suggestive of a microglial metabolism signaling pathway that could constitute a potential therapeutic target in the context of stroke.