Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants

Abstract

Mariangela Cavarelli et al. utilize cynomolgus macaque colorectal tissue explants to explore the effect of leukocytospermic seminal plasma (LSP) on SIVmac251 infection. Their results suggest that mucosal SIV infection is influenced by the inflammatory state of the semen donor, providing further insight into mucosal SIV pathogenesis.