Local aortic aneurysm wall expansion measured with automated image analysis

Abstract

Background: Assessment of regional aortic wall deformation (RAWD) might better predict for abdominal aortic aneurysm (AAA) rupture than the maximal aortic diameter or growth rate. Using sequential computed tomography angiograms (CTAs), we developed a streamlined, semiautomated method of computing RAWD using deformable image registration (dirRAWD). Methods: Paired sequential CTAs performed 1 to 2 years apart of 15 patients with AAAs of various shapes and sizes were selected. Using each patient’s initial CTA, the luminal and aortic wall surfaces were segmented both manually and semiautomatically. Next, the same patient’s follow-up CTA was aligned with the first using automated rigid image registration. Deformable image registration was then used to calculate the local aneurysm wall expansion between the sequential scans (dirRAWD). To measure technique accuracy, the deformable registration results were compared with the local displacement of anatomic landmarks (fiducial markers), such as the origin of the inferior mesenteric artery and/or aortic wall calcifications. Additionally, for each patient, the maximal RAWD was manually measured for each aneurysm and was compared with the dirRAWD at the same location. Results: The technique was successful in all patients. The mean landmark displacement error was 0.59 ± 0.93 mm with no difference between true landmark displacement and deformable registration landmark displacement by Wilcoxon rank sum test (P = .39). The absolute difference between the manually measured maximal RAWD and dirRAWD was 0.27 ± 0.23 mm, with a relative difference of 7.9% and no difference using the Wilcoxon rank sum test (P = .69). No differences were found in the maximal dirRAWD when derived using a purely manual AAA segmentation compared with using semiautomated AAA segmentation (P = .55). Conclusions: We found accurate and automated RAWD measurements were feasible with clinically insignificant errors. Using semiautomated AAA segmentations for deformable image registration methods did not alter maximal dirRAWD accuracy compared with using manual AAA segmentations. Future work will compare dirRAWD with finite element analysis–derived regional wall stress and determine whether dirRAWD might serve as an independent predictor of rupture risk. : Clinical Relevance: Current abdominal aortic aneurysm (AAA) surveillance methods are limited to assessments of the maximal diameter, which cannot accurately predict for AAA expansion and rupture risk. Automated assessment of AAA expansion across the entire three-dimensional geometry of the aneurysm could better describe aneurysm growth and could substantially inform management decisions, including the indications for repair. We have developed an accurate and streamlined approach to assessing local three-dimensional AAA expansion with submillimeter accuracy using computed tomography imaging obtained during routine aneurysm surveillance. This novel process does not require significant user expertise nor computer processing power and can be performed using open-source software readily accessible to both scientists and clinicians.

Keywords

• Aneurysms
• Biomechanics
• Computational analysis and simulation