Bioengineered human arterial equivalent and its applications from vascular graft to in vitro disease modeling
Xi Luo,
Zherui Pang,
Jinhua Li,
Minjun Anh,
Byoung Soo Kim,
Ge Gao
Affiliations
Xi Luo
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China
Zherui Pang
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China
Jinhua Li
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China; School of Medical Technology, Beijing Institute of Technology, Zhengzhou Academy of Intelligent Technology, Zhengzhou 450000, China; Beijing Institute of Technology, Zhuhai, Beijing Institute of Technology, Zhuhai 519088, China; Corresponding author
Minjun Anh
Medical Research Institute, Pusan National University, Yangsan 50612, Republic of Korea
Byoung Soo Kim
Medical Research Institute, Pusan National University, Yangsan 50612, Republic of Korea; School of Biomedical Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea; Corresponding author
Ge Gao
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China; School of Medical Technology, Beijing Institute of Technology, Zhengzhou Academy of Intelligent Technology, Zhengzhou 450000, China; Corresponding author
Summary: Arterial disorders such as atherosclerosis, thrombosis, and aneurysm pose significant health risks, necessitating advanced interventions. Despite progress in artificial blood vessels and animal models aimed at understanding pathogenesis and developing therapies, limitations in graft functionality and species discrepancies restrict their clinical and research utility. Addressing these issues, bioengineered arterial equivalents (AEs) with enhanced vascular functions have been developed, incorporating innovative technologies that improve clinical outcomes and enhance disease progression modeling. This review offers a comprehensive overview of recent advancements in bioengineered AEs, systematically summarizing the bioengineered technologies used to construct these AEs, and discussing their implications for clinical application and pathogenesis understanding. Highlighting current breakthroughs and future perspectives, this review aims to inform and inspire ongoing research in the field, potentially transforming vascular medicine and offering new avenues for preclinical and clinical advances.
