OncoImmunology (Dec 2025)
Updates on radiotherapy-immunotherapy combinations: Proceedings of 8th Annual ImmunoRad Conference
- Fereshteh Talebi,
- Fabiana Gregucci,
- Jalal Ahmed,
- Nir Ben Chetrit,
- Brian D. Brown,
- Timothy A. Chan,
- Dhan Chand,
- Julie Constanzo,
- Sandra Demaria,
- Dmitry I. Gabrilovich,
- Encouse Golden,
- Andrew Godkin,
- Chandan Guha,
- Gaorav P. Gupta,
- Aisha Hasan,
- Fernanda G. Herrera,
- Howard Kaufman,
- Donna Li,
- Alan A. Melcher,
- Sierra McDonald,
- Taha Merghoub,
- Arta M. Monjazeb,
- Sébastien Paris,
- Sean Pitroda,
- Anguraj Sadanandam,
- Dörthe Schaue,
- Laura Santambrogio,
- Phillippe Szapary,
- Julien Sage,
- James W. Welsh,
- Anna Wilkins,
- Kristina H. Young,
- Eric Wennerberg,
- Laurence Zitvogel,
- Lorenzo Galluzzi,
- Eric Deutsch,
- Silvia C. Formenti
Affiliations
- Fereshteh Talebi
- Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
- Fabiana Gregucci
- Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
- Jalal Ahmed
- Icahn Genomics Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Nir Ben Chetrit
- Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
- Brian D. Brown
- Icahn Genomics Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Timothy A. Chan
- Department of Cancer Sciences, Global Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA
- Dhan Chand
- Agenus Inc, Lexingston, MA, USA
- Julie Constanzo
- Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France
- Sandra Demaria
- Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
- Dmitry I. Gabrilovich
- AstraZeneca, Gaithersburg, MD, USA
- Encouse Golden
- Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
- Andrew Godkin
- Division of Infection and Immunity/Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff, UK
- Chandan Guha
- Departments of Radiation Oncology and Pathology, Albert Einstein College of Medicine, New York, NY, USA
- Gaorav P. Gupta
- Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
- Aisha Hasan
- Johnson & Johnson, New Brunswick, NJ, USA
- Fernanda G. Herrera
- AGORA Cancer Research Center, Swiss Cancer Center Leman, Lausanne, Switzerland
- Howard Kaufman
- Ankyra Therapeutics, Cambridge, MA, USA
- Donna Li
- University of Wisconsin, Madison, WI, USA
- Alan A. Melcher
- Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK
- Sierra McDonald
- UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
- Taha Merghoub
- Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA
- Arta M. Monjazeb
- Department of Radiation Oncology, University of California, San Diego, CA, USA
- Sébastien Paris
- Nanobiotix, Paris, France
- Sean Pitroda
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA
- Anguraj Sadanandam
- Division of Molecular Pathology, The Institute of Cancer Research, London, UK
- Dörthe Schaue
- Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
- Laura Santambrogio
- Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
- Phillippe Szapary
- Interventional Oncology, Johnson & Johnson, New Brunswick, NJ
- Julien Sage
- Departments of Genetics and Pediatrics, Stanford University, Stanford, California
- James W. Welsh
- Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
- Anna Wilkins
- Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK
- Kristina H. Young
- Division of Radiation Oncology, The Oregon Clinic, Portland, OR, USA
- Eric Wennerberg
- Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK
- Laurence Zitvogel
- Gustave Roussy, INSERM U1015, Division of Medicine, Paris-Saclay University, Center of Clinical Investigations BIOTHERIS, Villejuif, France
- Lorenzo Galluzzi
- Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA
- Eric Deutsch
- Department of Radiation Oncology, Gustave Roussy, INSERM U1030, Division of Medicine, Paris-Saclay University, RHU LySAIRI “Lymphocyte-Sparing Artificial Intelligence-guided Radio-Immunotherapy”, Villejuif, France
- Silvia C. Formenti
- Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
- DOI
- https://doi.org/10.1080/2162402x.2025.2507856
- Journal volume & issue
-
Vol. 14,
no. 1
Abstract
The annual ImmunoRad Conference has established itself as a recurrent occasion to explore the possibility of combining radiation therapy (RT) and immunotherapy (IT) for clinical cancer management. Bringing together a number of preclinical and clinical leaders in the fields of radiation oncology, immuno-oncology and IT, this annual event fosters indeed essential conversations and fruitful exchanges on how to address existing challenges to expand the therapeutic value of RT-IT combinations. The 8th edition of the ImmunoRad Conference, which has been held in October 2024 at the Weill Cornell Medical College of New York City, highlighted exciting preclinical and clinical advances at the interface between RT and IT, setting the stage for extra progress toward extended benefits for patients with an increasing variety of tumor types. Here, we critically summarize the lines of investigation that have been discussed at the occasion of the 8th Annual ImmunoRad Conference.
Keywords
- Abscopal effect
- CAR T cells
- CD8+ cytotoxic T lymphocytes
- low-dose radiation therapy
- TREG cells
- tumor-associated macrophages
